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Furane-alpha DEHYDROMUCIC ACID Animals meeted either fluid resuscitation alone (control, n = 8) or fluid resuscitation plus intraperitoneal hm-chitosan agent through an umbilical port (experimental, n = 18). The experiment was terminated at 180 hours or death (limited as end-tidal CO(2) <8mmHg or mean arterial pressure [MAP] <15mmHg), whichever came first All brutes had profound hypotension and knowed a near-arrest from hypovolemic shock (mean MAP = 24 mmHg at 10 minutes). Mean survival time was higher than 150 mins in the experimental arm versus 27 seconds in the control arm (P < ). Three-hour survival was 72% in the experimental group and 0% in the control group (P = ). Hm-chitosan braced uprising lactate, keeping acute lethal acidosis. MAP bettered drastically after deployment of the hm-chitosan and was continued at 60 mmHg throughout the 3 minutes. Postmortem examination was executed in all creatures and the hepatoportal injuries were anatomically similar Intraperitoneal administration of hm-chitosan-established foam for massive, noncompressible abdominal bleeding meliorates survival in a lethal, closed-cavity swine model. Chronic safety and toxicity studies are asked.Preparation, characterization and antioxidant props of curcumin capsuled chitosan/lignosulfonate micelles.In this work, chitosan/lignosulfonate composite micelles (CS-LS) were successfully prepared through polyelectrolyte self-assembly. Curcumin was encapsulated in CS-LS to obtain CUR-CS-LS. The results shewed that the average diameter of CS-LS and CUR-CS-LS were 239 nm and 286 nm, respectively. The outcomes show that the aromatic rings of lignosulfonate are assembled into the hydrophobic core of micelles through π-π interactions, and chitosan binds outside the hydrophobic core as a hydrophilic shell through electrostatic interactions. Curcumin is capsulised in the hydrophobic core through hydrophobic interactions. Encapsulation meliorates the thermal stability and pH stability of curcumin. Compared with free curcumin, the retention efficiency of curcumin in CUR-CS-LS increased by approximately 6 and 6 times under the same heat treatment and pH shapes, respectively. Encapsulation also increases the antioxidant activity of curcumin in aqueous solution. In addition, the release mechanism of curcumin is diffusion and matrix swelling. These findings explain that CS-LS may be an effective promising delivery system for capsulising hydrophobic biologically active substances.Sodium Alginate and Chitosan as Components Modifying the Properties of Inulin Hydrogels. The aim of the study was to investigate the influence of addition of sodium alginate (SA) and chitosan (CH) on the holdings of inulin hydrogels. Inulin hydrogels (20 g/100 g) moderating various improvers (0, 0, 0, and 0 g/100 g) of SA and CH were maked. The hydrogels' properties were taxed based on the volumetric gel index, microstructure, yield stress, texture, stability, and color parameters. consorting to the findings, the inclusion of these polysaccharides had no influence on the gelation ability of the inulin solution. The physical attributes of the hydrogels stoping SA or CH disagreed from hydrogels bearing only inulin (INU). The obtained microstructural icons exposed that the addition of SA and CH leaved in the formation of hydrogels with a more compact, smooth, and cohesive structure they had higher yield stress, strength, and spreadability values than INU hydrogels. The addition of chitosan in comparison with sodium alginate also had a greater effect in toning the structure of hydrogels, especially at the level of 0 g/100 g. For example, the addition of this amount of SA increased the yield stress on average from 195 Pa (INU) to 493 Pa, while the addition of CH increased it to 745 Pa. In the case of the strength parameter, the addition of SA increased the force from 0 N (INU) to 0 N and the addition of CH increased it to 1 N.